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Bueng Si Fai is about 200 miles north of Thailand's capital city Bangkok, and it's an important freshwate… Bueng Si Fai is about 200 miles north of Thailand's capital city Bangkok, and it's an important freshwater fish breeding ground. Of the four WNK isoforms, much of the focus has been on WNK1, which is activated in response to osmotic stress by phosphorylation of its T-loop residue (Ser 382). The role of Cl– as an intracellular signaling ion has been increasingly recognized in recent years. Wega di Number Kòrsou. 877. Results: Stroke triggered a 2- to 5-fold increase of WNK (isoforms 1, 2, 4), SPAK/OSR1 (oxidative stress-responsive kinase 1), and NKCC1 protein in the ang II–infused hypertensive mouse brains at 24 hours after stroke, which was associated with increased nuclear translocation of phospho-NF-κB protein in the cortical neurons (a Pearson correlation r of 0. 6. 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